منابع مشابه
Bile Acids in Neurodegenerative Disorders
Bile acids, a structurally related group of molecules derived from cholesterol, have a long history as therapeutic agents in medicine, from treatment for primarily ocular diseases in ancient Chinese medicine to modern day use as approved drugs for certain liver diseases. Despite evidence supporting a neuroprotective role in a diverse spectrum of age-related neurodegenerative disorders, includin...
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There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis. This evidence includes the direct genetic evidence of pathogenic mutations in mitochondrial proteins in inherited Parkinsonism {such as PA...
متن کاملThe mitochondrial genome, aging and neurodegenerative disorders.
Mitochondria contain the only extra-nuclear source of DNA. Under evolutionary pressure mitochondrial DNA (mtDNA) has adapted from genomes containing over 1,000 kb containing significant quantities of non-coding DNA to the highly compact mammalian mtDNA. In humans, the mitochondrial genome consists of a small (16.5 kb) double-stranded circular genome constituting less than 1% of the total cellul...
متن کاملFatty acids and neuropsychiatric disorders
In 1937, after qualifying as a medical doctor and before taking up his appointment as a fellow at Magdalen College, Oxford, Hugh Sinclair visited Herbert Evans, the codiscoverer with Katherine Scott Bishop of vitamin E, and became interested in the possibility that some fatty acid deficiencies might account for the rise in ischaemic heart disease in the Western world [1,2]. In his research lett...
متن کاملEffects of omega 3 fatty acids supplementation in behavior and non-neurodegenerative neuropsychiatric disorders.
This work provides a systematic review of all published randomised, controlled clinical trials (RCT) investigating the effects of n-3 PUFA intake on the prevention and treatment of non-neurodegenerative neuropsychiatric disorders. Five databases (PubMed, EMBASE, LILACS, CINAHL and The Cochrane Database) were searched for RCT in this area published up to April 2011. The selected studies all invo...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2020
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858420936162